Graduates' Master's projects – University of Copenhagen

Graduations 

The following Master students have defended their Master thesis and has attained the title as Master of Companion Animal Clinical Science (MS CACS) within their individual specialization.

Anne Marie Fog-Larsen, DVM, MS CACS (Internal Medicine)

 In March 2018 Anne Marie Fog-Larsen defended her Master’s thesis ”Characterization of Alopecia X across breeds. A systematic review”. Master’s thesis brief:

Background: Alopecia X is an adult onset hair growth disorder seen primarily in double coated breeds such as Pomeranian, Alaskan Malamute, Samoyed, Keeshond and Siberian husky but has also been described in Miniature and Toy Poodles. The syndrome is poorly understood and it has never been proven whether Alopecia X can be considered a single distinct disease with the exact same etiology across breeds.
Objective: based on a systematic review of peer-reviewed scientific literature the aim of this study was to investigate whether Alopecia X can be considered a single distinct disease across breeds or whether the syndrome differs so much from breed to breed that it more appropriately should be considered different individual breed specific diseases.
Conclusions: Alopecia X is by far best elucidated in Pomeranians both in terms of clinical signs, histopathology, hormone analysis, response to different types of treatment and genetic analysis. The question of whether Alopecia X can be considered a distinct disease across breeds or more appropriately should be considered different breed specific diseases could not be answered due to the low number of dogs (other than Pomeranians) representing each breed and the heterogeneity, low evidence quality and poor methodological quality of the studies included in this systematic review. Well-designed and adequately powered studies with the purpose of accurately characterizing the disease at breed level are warranted.
 

Ásdís Linda Sverrisdóttir, DVM, MS CACS (Internal Medicine)

In February 2018 Ásdís Linda Sverrisdóttir defended her Master’s thesis  “What is the diagnostic usefulness of the Coombs' test for Immune Mediated Hemolytic Anemia in dogs”. Master’s thesis brief:

Background: Immune mediated hemolytic anemia (IMHA) is serious disease and one of the most common immune mediated disease in dogs. IMHA has often poor outcome and high mortality rate.
Objective of this study was to do a literature review on the usefulness of the Coombs' tests in the diagnosis of Immune mediated hemolytic anemia. 
The Coombs' test detects the immune reaction in the disease. The specificity is good but the disadvantage of the test is its low sensitivity. The patient selection is important to increase the tests sensitivity and good clinical workup before running the test. Excluding concurrent diseases of non-immune mediated origin is important. The Coombs' test is usually run on polyvalent reagent at 37°C but running the test with both poly and monovalent at 4°C and 37°C will increase the sensitivity of the test. The use of dilute multiple sera beyond the manufactures guidance will also increase the sensitivity of the test. The pattern of the test with monovalent reagent can give us knowledge of different immunoglobulins that may indicate different pathogenesis of the anemia. This can give us hint in distinguish between primary and secondary IMHA or anemia of non-immune mediated cause.
Conclusion of this study is that the test is useful and important in the diagnosis of immune reaction and the only test on the market that is widely available today.

 

Tine Bondo, DVM, MS CACS (Internal Medicine)

In March 2018 Tine Bondo defended her Master’s thesis “Evidence based medicine regarding SDMA as an early biomarker of chronic kidney disease in cats”. Master’s thesis brief:

Background: CKD is a commonly recognized disease in cats, but diagnosing it early is challenging. SDMA concentration has been investigated and found to be highly correlated with GFR in humans. It would be added value to practitioners in veterinary medicine to know, whether SDMA can help diagnosing cats with CKD earlier. A systematic review was performed.
Objective: The objective of this study was to look for evidence based medicine concerning the use of symmetric dimethylarginine (SDMA) as an early biomarker of Chronic Kidney Disease in cats. 0Hypothesis: “No difference is seen in time of diagnosis of Chronic Kidney Disease (CKD) in cats when Symmetric Dimethylarginine (SDMA) is used as biomarker compared to creatinine”
Methods: A review was performed searching AGRICOLA, AGRIS, CAB Abstracts, Embase, Ovid MEDLINE
Conclusions and clinical importance: SDMA seems to be a helpful parameter when assessing kidney function in cats with suspicion of early chronic kidney disease (CKD) (or other kidney related disease) and the 0hypothesis: “No difference is seen in time of diagnosis of Chronic Kidney Disease (CKD) in cats, when SDMA is used as biomarker compared to creatinine” can therefore not be accepted. Based on the very limited amount of studies evidence based use of SDMA as an early indicator of CKD in cats is a challenge. Given the facts that diagnosis of CKD can be challenging, SDMA can be included as a part of routine examinations in cats suspected to have CKD contributing to the diagnosis as a part of the puzzle, but acknowledging that so far it is based on a limited amount of studies and hence limited evidence in cats.
 

Anders Jensen, DVM, MS CACS (Internal Medicine)

In June 2017 Anders Jensen defended his Master’s thesis "Evidence Based medicine concerning clinical effects of Probiotics in treatment or prevention of gastrointestinal diseases in dogs"

Master’s thesis brief: (abstract not public)

Christina H. Gulløv, DVM, MS CACS (Surgery)

In June 2017 Christina H. Gulløv defended her Master’s thesis: The Effect of Early Neutering on Lifespan in Dogs - A Systematic Review" 

Master’s thesis brief: (abstract not public)

Lars Langerhuus, DVM, MS CACS (Surgery) 

In January 2017 Lars Langerhuus defended his Master's thesis: Proportion recovery and times to ambulation Proportion recovery and times to ambulation for non-ambulatory dogs with thoracolumbar disc extrusions treated with hemilaminectomy or conservative treatment: A systematic review and meta-analysis of case-series studies

Ken Lindeblad, DVM, MS CACS (Surgery)

In January 2015 Ken Lindeblad defended his Master's thesis: A systematic review of meniscal injury diagnosis in dogs

Gert Jarn Pedersen, DVM, MS CACS (Surgery)

In January 2015 Ken Lindeblad defended his Master's thesis: Ulnar osteotomy for premature closure of the distal ulnar growth plate: how and when?

Irene Krøjer Hansen, DVM, MS CACS (Surgery)

In January 2015 Irene Krøjer Hansen defended her Master's thesis "Does the perioperative use of antibiotics reduce the occurrence of postoperative surgical site infections in dogs and cats? A Minireview" 

Master’s thesis brief: (abstract not public)


Graduates from Internal Medicine Specialisation